Key result
A 1 standard deviation increment in handgrip strength was significantly associated with higher odds of hypertension (OR 1.85) in older men with high CD34-positive cell levels, but not in those with low levels.
Why the study?
Because handgrip strength and blood pressure are both linked to endothelial condition, the activity of endothelial repair might influence their association.
Is handgrip strength associated with hypertension differently based on circulating CD34-positive cell levels in older Japanese men?
Cross-Sectional (n=257)
No
Is handgrip strength associated with hypertension differently based on circulating CD34-positive cell levels in older Japanese men?
Odds Ratio: 1.85 (95% CI 1.19–2.88)
The positive association between handgrip strength and hypertension in older Japanese men is limited to those with high levels of circulating CD34-positive cells, suggesting a role for vascular homeostasis.
May inform endothelial assessment in older men with hypertension; leaves open whether CD34+ cells mediate handgrip-BP links in longitudinal studies.
BACKGROUND: A positive association between handgrip strength and blood pressure has been reported. Since these factors are linked to the condition of the endothelium, the activity of endothelial repair might influence the association between handgrip strength and hypertension. METHODS: A cross-sectional study was conducted with 257 Japanese men aged 60-69 years who underwent an annual health checkup. As individuals with high level of circulating CD34-positive cells might show active endothelial repair, which plays an important role in vascular homeostasis, participants were stratified by circulating CD34-positive cell levels, using the median value of this population (0.96 cells/μL) as the cutoff. RESULTS: Independent of known cardiovascular risk factors, for participants with a high CD34-positive cell, handgrip strength is significantly positively associated with hypertension (odds ratio and 95% confidence interval of hypertension for 1 standard deviation increment of handgrip strength were 1.85 (1.19, 2.88) but not for participants with a low CD34-positive cell (0.91 (0.61, 1.37)). CONCLUSION: The positive association between handgrip strength and hypertension is limited to high CD34-positive cells. This result may help clarify the role of vascular homeostasis in maintaining muscle strength.
No takes yet. Share an insight, caveat, or question.
Shimizu et al. (2021) conducted a cross-sectional in Hypertension (n=257). Handgrip strength (1 SD increment) vs. Participants with low CD34-positive cell levels was evaluated on Hypertension (OR 1.85, 95% CI 1.19-2.88). A 1 standard deviation increment in handgrip strength was significantly associated with higher odds of hypertension (OR 1.85) in older men with high CD34-positive cell levels, but not in those with low levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: