Key result
In children with juvenile rheumatoid arthritis on an 8-hourly aspirin regimen, the ratio of 0 to 8 hour total salicylate concentrations was 0.95 ± 0.10, indicating blood sample timing is not critical.
Why the study?
Does the timing of blood sampling affect the accuracy of steady-state serum salicylate concentration monitoring in children with juvenile rheumatoid arthritis on an 8-hourly aspirin regimen?
Population
17 children (age: 4-17 years) with definite juvenile rheumatoid arthritis
Design
Cohort
Follow-up
8 hours
Authors
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May support flexible sampling for salicylate monitoring in JRA; leaves open prospective validation before practice change.
Observational (n=17)
Does the timing of blood sampling affect the accuracy of steady-state serum salicylate concentration monitoring in children with juvenile rheumatoid arthritis on an 8-hourly aspirin regimen?
Timing of blood sampling is not critical for monitoring steady-state serum salicylate concentrations in the usual therapeutic range if the dosing interval is 8 hours or less.
Pachman et al. (1979) conducted an observational in juvenile rheumatoid arthritis (n=17). Aspirin (salicylate therapy) was evaluated on Free and total salicylate concentrations in serum. In children with juvenile rheumatoid arthritis on an 8-hourly aspirin regimen, the ratio of 0 to 8 hour total salicylate concentrations was 0.95 ± 0.10, indicating blood sample timing is not critical.
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