Variation in Rate of Salicylate Elimination by Humans

Seventeen healthy human subjects, consisting of seven men and ten women, aged 23 to 53, weighing 52 to 96 kg., were given 1 g. ( three 0.33-g. tablets) of aspirin on an empty stomach. Blood samples were taken two, four, six, eight, and in most cases also 10 hours after drug administration. Plasma salicylate concentrations were determined by the colorimetric method of Trinder (1954). After one week the test was repeated.