Key result
Chronic aspirin ingestion (60 mg/kg daily) for 20 days in healthy volunteers caused a steady decrease in salicylic acid plasma levels, dropping to 48% of peak Day 7 values by Day 21 in 5 subjects.
Why the study?
Does chronic aspirin ingestion affect steady-state salicylic acid plasma levels in healthy volunteers?
Population
6 healthy volunteers
Design
Cohort
Follow-up
21 days
Authors
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May reduce steady-state salicylate exposure with prolonged use; leaves open relevance for efficacy or dosing in patients.
Does chronic aspirin ingestion affect steady-state salicylic acid plasma levels in healthy volunteers?
Chronic aspirin ingestion leads to a steady decrease in steady-state salicylic acid plasma levels after an initial peak, which has implications for long-term therapy and drug interactions.
Müller et al. (1975) studied healthy volunteers (n=6). Aspirin was evaluated on salicylic acid plasma levels. Chronic aspirin ingestion (60 mg/kg daily) for 20 days in healthy volunteers caused a steady decrease in salicylic acid plasma levels, dropping to 48% of peak Day 7 values by Day 21 in 5 subjects.
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