Symptomatic and functional effects of N-Acetylcysteine in primary acquired nasolacrimal stenosis

Purpose: To research the effects of N-Acetylcysteine on lacrimation complaint and the opening of the nasolacrimal duct in the cases with primary acquired nasolacrimal duct stenosis (PANS). Materials and methods:A total of 56 patients aged between 16-69 were diagnosed with PANS was started the treatment with NAS four drops per a day.The presence of epiphora and feeling of watering in the nasal passage with nasolacrimal canal (NLC) lavage before drug use was compared after one month of treatment.Results: Twenty-seven (48.21%) of 56 patients had a feeling of nasal watering with lavage.In 32 (57.14%) of the patients, it was found that subjectively watering and epiphora were decreased.Recurrence was observed in 30 of 56 patients (53.57%) at the end of the treatment of 3 months. Conclusion:In the patients with PANS due to mucus plug formation, NAS may provide symptomatic and functional success.It may be considered in the treatment of patients who are not suitable for surgery or who do not want surgery.As a next step, the lavage of NLC with NAS can provide more effective and long-term results.