Key result
Lidocaine and procaineamide inhibit calcium transport by cardiac sarcoplasmic reticulum only at high concentrations, with no significant differences found between the two agents.
Lidocaine and procaineamide inhibit calcium transport in canine cardiac microsomes only at high concentrations, with no significant difference between the two agents to explain their differing electrophysiological effects.
Does not implicate calcium transport inhibition in differing effects of lidocaine versus procainamide; leaves open other mechanisms for investigation.
Local anaesthetics inhibit calcium transport by cardiac sarcoplasmic reticulum. However, the concentrations of lidocaine and procaineamide needed to produce these effects are high. No significant differences were found between these agents that could account for reported differences in their electrophysiological effects.
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Katz et al. (1975) studied this question. Lidocaine and procaineamide inhibit calcium transport by cardiac sarcoplasmic reticulum only at high concentrations, with no significant differences found between the two agents.
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