Why the study?
Do anesthetic agents reduce calcium uptake in canine myocardial sarcoplasmic reticulum?
Population
canine myocardial sarcoplasmic reticulum
Design
Preclinical
Authors
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May explain differential negative inotropy of select anesthetics in canine SR; leaves open human relevance and clinical implications.
Do anesthetic agents reduce calcium uptake in canine myocardial sarcoplasmic reticulum?
The negative inotropic effects of chloroform and sodium pentobarbital may be mediated by inhibition of sarcoplasmic reticulum calcium uptake, whereas halothane and ether likely act through different mechanisms.
Lain et al. (1968) studied this question.
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