Key result
Atomic Force Microscopy revealed that the sarcolemma of intact skeletal muscle fibres features periodic transversal foldings corresponding to sarcomere length, with crests exhibiting higher stiffness.
Population
Single skeletal muscle fibres enzymatically dissociated from Flexor Digitorum Brevis of adult mice
Design
Preclinical
Authors
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Baseline AFM topography in healthy fibers; hypothesis-generating for dystrophic models and should not yet change practice.
This study provides the first complete three-dimensional topography and mechanical characterization of intact, living skeletal muscle fibres, establishing a baseline for future studies on dystrophic muscles.
Defranchi et al. (2005) studied Healthy skeletal muscle fibres. Atomic Force Microscopy (AFM) was evaluated on Three-dimensional structure and elastic properties of the sarcolemma. Atomic Force Microscopy revealed that the sarcolemma of intact skeletal muscle fibres features periodic transversal foldings corresponding to sarcomere length, with crests exhibiting higher stiffness.
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