Key result
Treatment with multidrug vasodilators and metabolic correction for 24-36 months increased peritubular capillary flow and renal function in 50 normoalbuminuric diabetic patients.
Why the study?
Does multidrug vasodilator therapy improve peritubular capillary flow and renal function in normoalbuminuric diabetic patients?
Does multidrug vasodilator therapy improve peritubular capillary flow and renal function in normoalbuminuric diabetic patients?
Early intervention with multidrug vasodilators and metabolic correction in normoalbuminuric diabetic patients may improve renal perfusion and function, potentially preventing end-stage renal disease.
Answers are grounded in this paper and cite their sources.
May support early renal protection in normoalbuminuric diabetes; hypothesis-generating and requires randomized confirmation before practice change.
Under common practice, treatment of diabetic nephropathy (DN) is usually initiated at late stage of CKD due to the insensitiveness of the available diagnostic markers. Such treatment fails to restore renal perfusion and function. This is due to the defective mechanism of vascular homeostasis and impaired nitric oxide production observed in late stage of DN. In contrast, the mechanism of vascular repair is adequately functional in early stage of DN (normoalbuminuria). In this study, we treated 50 normoalbuminuric diabetic patients with multidrug vasodilators, namely ACE inhibitor, angiotensin receptor blocker, ± calcium channel blocker in conjunction with correction of metabolic disorders for 24-36 months. Following the treatment, increment in peritubular capillary flow in response to vasodilators was observed, and thus supports the adequate role of vascular repair. In addition, increase in renal function documented in this study also implies that an effective preventive strategy to minimize end-stage renal disease can be accomplished in normoalbuminuric DN.
No takes yet. Share an insight, caveat, or question.
Futrakul et al. (2011) studied Normoalbuminuric Type 2 Diabetic Nephropathy (n=50). Multidrug vasodilators (ACE inhibitor, angiotensin receptor blocker, ± calcium channel blocker) and correction of metabolic disorders was evaluated on Peritubular capillary flow and renal function. Treatment with multidrug vasodilators and metabolic correction for 24-36 months increased peritubular capillary flow and renal function in 50 normoalbuminuric diabetic patients.
Synapse has enriched 10 related papers. Consider them for comparative context: