Key result
Myxomatous valvar tissue showed significantly increased decorin mRNA expression compared with normal tissue (211 vs 100, p<0.02).
Authors
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Does not yet alter valve disease management; leaves open decorin's mechanistic or therapeutic role pending validation.
Case-Control (n=8)
Absolute Event Rate: 211% vs 100%
p-value: p=<0.02
Radermecker et al. (2003) conducted a case-control in Mitral valve prolapse (n=8). Myxomatous valvar tissue vs. Normal valvar tissue was evaluated on Decorin mRNA expression (p=<0.02). Myxomatous valvar tissue showed significantly increased decorin mRNA expression compared with normal tissue (211 vs 100, p<0.02).
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