Key result
Simultaneous introduction of experimental hyperthyroidism and compensatory hypertrophy resulted only in hyperthyroid effects, indicating hyperthyroidism is the dominant regulator of myosin expression.
Why the study?
Does hyperthyroidism or compensatory hypertrophy dominate the regulation of skeletal muscle myosin expression?
Population
Animal model studying skeletal muscle (plantaris and soleus muscles of the hindlimb)
Comparison
Simultaneous experimental hyperthyroidism and… vs Hyperthyroidism alone and compensatory…
Design
Preclinical
Follow-up
40 days
Authors
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Hyperthyroidism may predominate in myosin regulation amid hypertrophy; hypothesis-generating for human muscle or cardiac translation.
Does hyperthyroidism or compensatory hypertrophy dominate the regulation of skeletal muscle myosin expression?
Hyperthyroidism is the dominant regulator of skeletal muscle myosin expression over physiological demand (hypertrophy).
Ianuzzo et al. (1991) studied this question. Simultaneous experimental hyperthyroidism and compensatory hypertrophy vs. Hyperthyroidism alone or hypertrophy alone was evaluated on Phenotypic expression of skeletal muscle myosin. Simultaneous introduction of experimental hyperthyroidism and compensatory hypertrophy resulted only in hyperthyroid effects, indicating hyperthyroidism is the dominant regulator of myosin expression.
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