Key result
Thyroid hormone manipulation altered striated muscle isomyosin expression, with thyroid deficiency increasing the V3 isoform by 20- and 49-fold in the left and right ventricles, respectively.
Population
Adult female rats
Comparison
Thyroid hormone manipulation for 6-8 weeks vs Euthyroid controls
Design
Preclinical, randomly assigned
Follow-up
6-8 weeks
Authors
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Thyroid effects on rat ventricular myosin isoforms warrant clinical caution in extrapolation; leaves open mechanistic roles in human cardiac remodeling.
RCT
Randomly assigned to one of three groups
Thyroid hormone levels exert specific and differential effects on myosin isoform expression across different types of striated muscle in rats.
Fitzsimons et al. (1990) conducted an RCT in Altered thyroid state. Thyroid hormone manipulation (propylthiouracil or triiodothyronine) vs. Euthyroid controls was evaluated on Striated muscle isomyosin expression. Thyroid hormone manipulation altered striated muscle isomyosin expression, with thyroid deficiency increasing the V3 isoform by 20- and 49-fold in the left and right ventricles, respectively.
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