Key result
Prolonged electrical silence of a mixed fast hindlimb extensor for 6 months resulted in virtually all fibers expressing fast MHC and enzyme profiles typical of fast glycolytic fibers.
Why the study?
Does prolonged neuromuscular inactivity via spinal cord isolation alter the enzymatic profiles and fiber types in adult cat medial gastrocnemius muscle?
Population
Adult cat medial gastrocnemius (MG) muscle fibers
Comparison
Spinal cord isolation for 6 months vs Control (normal neuromuscular activity)
Design
Preclinical
Follow-up
6 months
Authors
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Does not guide human disuse management; leaves open translation of feline fast-fiber remodeling to clinical inactivity.
Does prolonged neuromuscular inactivity via spinal cord isolation alter the enzymatic profiles and fiber types in adult cat medial gastrocnemius muscle?
Prolonged electrical silence of a mixed fast hindlimb extensor in cats results in virtually all fibers expressing fast MHC and enzymatic profiles typical of fast glycolytic fibers.
Roy et al. (1991) studied Chronic inactivity. Spinal cord isolation (chronic inactivity) vs. Control was evaluated on Enzymatic profiles and cross-sectional area of single fibers in the medial gastrocnemius. Prolonged electrical silence of a mixed fast hindlimb extensor for 6 months resulted in virtually all fibers expressing fast MHC and enzyme profiles typical of fast glycolytic fibers.
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