Key result
Preoperative SARS-CoV-2 infection increases the risk for 30-day postoperative major adverse cardiovascular and cerebrovascular events, with risk influenced by disease severity and time to surgery.
Why the study?
With more surgical patients having a prior history of COVID-19, understanding the impact of SARS-CoV-2 infection on postoperative cardiovascular and cerebrovascular risk is crucial.
Does preoperative SARS-CoV-2 infection increase the risk of postoperative major adverse cardiovascular and cerebrovascular events (MACE) in patients undergoing noncardiac surgery?
Cohort
Yes
Does preoperative SARS-CoV-2 infection increase the risk of postoperative major adverse cardiovascular and cerebrovascular events (MACE) in patients undergoing noncardiac surgery?
Preoperative SARS-CoV-2 infection increases the risk of early postoperative cardiovascular complications in noncardiac surgery, emphasizing the need to stratify time-to-surgery guidelines based on COVID-19 disease severity.
Prior COVID-19 was associated with increased postoperative MACE; leaves open optimal timing and severity thresholds for risk stratification.
With an increasing proportion of patients undergoing surgery with a prior history of COVID-19, it is crucial to understand the impact of SARS-CoV-2 infection on postoperative cardiovascular/cerebrovascular risk. Our work assesses a large, national, multi-institutional cohort of patients to highlight that COVID-19 infection increases risk for postoperative major adverse cardiovascular and cerebrovascular events (MACE). MACE risk is influenced by an interplay between disease severity and time between infection and surgery, and full vaccination reduces the risk for 30-day postoperative MACE. These results highlight the importance of stratifying time-to-surgery guidelines based on disease severity.
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SenthilKumar et al. (2023) conducted a cohort in Patients undergoing noncardiac surgery. Preoperative SARS-CoV-2 infection was evaluated on postoperative major adverse cardiovascular and cerebrovascular events (MACE). Preoperative SARS-CoV-2 infection increases the risk for 30-day postoperative major adverse cardiovascular and cerebrovascular events, with risk influenced by disease severity and time to surgery.
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