Key result
Periodic stimulation of a nonlinear cardiac oscillator in vitro and in simplified models produces complex dynamics, including phase-locked and chaotic rhythms similar to clinical observations.
In vitro and mathematical models of cardiac oscillators demonstrate that periodic stimulation can induce chaotic rhythms analogous to complex clinical arrhythmias.
Answers are grounded in this paper and cite their sources.
Supports model-based arrhythmia research; leaves open translation to human electrophysiology.
Periodic stimulation of a nonlinear cardiac oscillator in vitro gives rise to complex dynamics that is well described by one-dimensional finite difference equations. As stimulation parameters are varied, a large number of different phase locked and chaotic rhythms is observed. Similar rhythms can be observed in the intact human heart when there is interaction between two pacemaker sites. Simplified models are analysed, which show some correspondence to clinical observations.
No takes yet. Share an insight, caveat, or question.
Glass et al. (1987) studied Complex cardiac arrhythmias. Periodic stimulation of a nonlinear cardiac oscillator was evaluated on Complex dynamics, phase locked and chaotic rhythms. Periodic stimulation of a nonlinear cardiac oscillator in vitro and in simplified models produces complex dynamics, including phase-locked and chaotic rhythms similar to clinical observations.
Synapse has enriched 10 related papers. Consider them for comparative context: