Key result
Nonlinear oscillator model with delayed Duffing-type connections successfully generates synthetic normal and pathological ECGs.
A mathematical model using nonlinear oscillators with Duffing-type connections can effectively simulate a wide range of normal and pathological cardiac rhythms on synthetic ECGs.
Coupled nonlinear oscillator model generates synthetic ECGs; leaves open validation before research or clinical use.
Heartbeat rhythms are related to a complex dynamical system based on electrical activity of the cardiac cells usually measured by the electrocardiogram (ECG). This paper presents a mathematical model to describe the electrical activity of the heart that consists of three nonlinear oscillators coupled by delayed Duffing-type connections. Coupling alterations and external stimuli are responsible for different cardiac rhythms. The proposed model is employed to build synthetic ECGs representing a variety of responses including normal and pathological rhythms: ventricular flutter, torsade de pointes, atrial flutter, atrial fibrillation, ventricular fibrillation, polymorphic ventricular tachycardia and supraventricular extrasystole. Moreover, the sinoatrial rhythm variations are described by time-dependent frequency, representing transient disturbances. This kind of situation can represent transitions between different pathological behaviors or between normal and pathological physiologies. In this regard, a nonlinear dynamics perspective is employed to describe cardiac rhythms, being able to represent either normal or pathological behaviors.
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Fonkou et al. (2023) studied Cardiac arrhythmias. Mathematical model with delayed Duffing-type connections was evaluated on Generation of synthetic ECGs representing normal and pathological rhythms. A mathematical model consisting of three nonlinear oscillators coupled by delayed Duffing-type connections successfully generated synthetic ECGs representing normal and pathological cardiac rhythms.
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