Key result
Severe hyperglycemia markedly improves postischemic heart function and reduces reperfusion arrhythmias in diabetic rat hearts.
Population
Isolated hearts from 3-week streptozocin-induced type 1 diabetic rats
Comparison
Severe hyperglycaemia and hyperosmotic… vs Normal control rats and mild hyperglycaemia
Design
Preclinical
Follow-up
30 min ischaemia and 30 min reperfusion
Authors
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Caution against assuming uniform harm from severe hyperglycaemia in diabetic ischaemia; leaves open whether HSP90 upregulation extends cardioprotection to clinical settings.
Short-term type 1 diabetes with severe hyperglycemia paradoxically enhances myocardial tolerance to ischemia-reperfusion injury, potentially mediated by increased osmolarity and elevated hsp90.
Chen et al. (2006) studied Type 1 diabetes and myocardial ischaemia. Severe hyperglycaemia (blood glucose > 20 mmol/L) vs. Normal control rats was evaluated on Postischaemic heart function and reperfusion arrhythmias. Severe hyperglycaemia (>20 mmol/L) in short-term type 1 diabetic rat hearts markedly improved postischaemic heart function and reduced reperfusion arrhythmias compared with normal controls.
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