Key result
Oral administration of 0.2% Amino-Zinc complex significantly increased the foot-and-mouth disease vaccine structural protein antibody positivity rate to 90% compared to 55% with vaccine alone at 4 weeks post-vaccination.
Why the study?
Foot-and-mouth disease vaccines and adjuvants require an extended period to produce sufficient antibodies to prevent viral infection.
Does oral Amino-Zn administration increase FMD vaccine SP antibody positivity rates in piglets?
RCT (n=100)
Randomly assigned
Yes
Does oral Amino-Zn administration increase FMD vaccine SP antibody positivity rates in piglets?
Absolute Event Rate: 90% vs 55%
p-value: p=<0.05
Oral administration of Amino-Zn enhances the antibody titer and immunogenicity of the FMD vaccine in pigs.
Supports Amino-Zn adjuvant exploration in pigs; hypothesis-generating animal data with no practice implications.
Foot-and-mouth disease (FMD) is a highly contagious animal disease that occurs in cloven-hoofed animals including pigs. To prevent FMD, vaccines and adjuvants are routinely used to induce an immune response; however, it requires an extended period of time to produce sufficient antibodies to prevent viral infection. In this study, we evaluated the increased effectiveness of the FMD vaccine structural protein (SP) antibody by administrating the Amino–Zn adjuvant to 100 pigs from 3 test pig farms in their feed. The FMD vaccine antibody titer and immunological index were analyzed using an enzyme-linked immunosorbent assay (ELISA) kit, and the hematological and blood biochemical parameters were analyzed using an automatic blood analyzer. The titer of the FMD vaccine SP antibodies in the 0.2% Amino–Zn-administered group was significantly increased compared to that of the positive control group only injected with FMD vaccine at 4 weeks after the first vaccination and at 4, 8, and 16 weeks after the second vaccination (p < 0.05). The FMD vaccine SP antibody positive rate was 100% until shipment. The IFN-γ and IgA levels were significantly increased by Amino–Zn administration 4 weeks after the first vaccination and 4 weeks after the second vaccination (p < 0.05). On the other hand, serum AST, and CPK (p < 0.001) were significantly decreased by Amino–Zn administration. These results show that the administration of Amino–Zn is effective in enhancing the antibody titer and immunogenicity of the FMD vaccine and can be used as an oral adjuvant (OrAd) to prevent viral diseases, such as FMD.
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Lee et al. (2023) conducted an RCT in Foot-and-mouth disease vaccination (n=100). Amino-Zinc complex vs. Vaccination only (positive control) or no vaccination/no Amino-Zn (negative control) was evaluated on FMD vaccine structural protein antibody positivity rate at 4 weeks after primary vaccination (95% CI 57.6-89.9, p=<0.05). Oral administration of 0.2% Amino-Zinc complex significantly increased the foot-and-mouth disease vaccine structural protein antibody positivity rate to 90% compared to 55% with vaccine alone at 4 weeks post-vaccination.
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