Key result
Oral administration of 0.2% Zinc-Aspartic Acid significantly increased FMD vaccine SP antibody titers compared to FMD vaccine alone (p<0.05).
Why the study?
Existing vaccines and adjuvants used to induce an immune response against FMD are not sufficient to prevent viral infection.
Does oral Zinc-Aspartic Acid improve FMD vaccine SP antibody positive rates in vaccinated pigs?
Does oral Zinc-Aspartic Acid improve FMD vaccine SP antibody positive rates in vaccinated pigs?
p-value: p=<0.05
Oral administration of Zinc-Aspartic Acid acts as an effective adjuvant to enhance the antibody titer and immune response to the FMD vaccine in pigs.
May boost FMD vaccine titers in pigs; hypothesis-generating and requires validation before any veterinary use.
FMD is a highly contagious animal disease that occurs in cloven-hoofed animals including pigs. To prevent FMD, vaccines and adjuvants are used to induce an immune response, but it is not sufficient to show the effect of preventing viral infection. In this study, we conducted to evaluate the increasing effect of FMD vaccine SP antibody by administrating Zn-ASP to 100 pigs from three test pig farms with feed. FMD vaccine antibody titer and immunological index were analyzed using an enzyme-linked immunosorbent assay (ELISA) kit, and hematological and blood biochemical parameters were analyzed using an automatic blood analyzer. The titer of FMD vaccine SP antibody in the 0.2% Zn-ASP-administered group significantly increased compared to that in the positive control group only injected with FMD vaccine at 4 weeks after the first vaccination and at 4, 8 and 16 weeks after the second vaccination, respectively (p<0.05). The FMD vaccine SP antibody positive rate was 100% until shipment. IFN-γ and IgA were significantly increased by Zn-ASP administration 4 weeks after the first vaccination and 4 weeks after the second vaccination (p<0.05). On the other hand, serum AST, and CPK (p<0.001) were significantly decreased by Zn-ASP. Our results show that the administration of Zn-ASP is effective in enhancing the antibody titer and immunity of the FMD vaccine by FMD vaccination, and it is thought that it can be used as an oral adjuvant (OrAd) to prevent viral diseases such as FMD.
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Lee et al. (2023) studied Foot-and-Mouth Disease (FMD) (n=100). Zinc-Aspartic Acid (Zn-ASP) vs. FMD vaccine alone was evaluated on FMD vaccine SP antibody titer (p=<0.05). Oral administration of 0.2% Zinc-Aspartic Acid significantly increased FMD vaccine SP antibody titers compared to FMD vaccine alone (p<0.05).
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