Key result
Transcutaneous vagus nerve stimulation reduced systemic tumor necrosis factor and HMGB1 levels, and improved survival in mice with polymicrobial sepsis.
Why the study?
Does transcutaneous vagus nerve stimulation improve survival and reduce proinflammatory cytokines in mice with sepsis?
Population
Male BALB/c mice with lethal endotoxemia or polymicrobial sepsis
Comparison
Electrical or transcutaneous vagus nerve… vs Sham vagus nerve stimulation
Design
Preclinical, randomized
Authors
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Hypothesis-generating for transcutaneous vagus nerve stimulation in sepsis; human trials needed before clinical adoption.
RCT
randomized
No
Does transcutaneous vagus nerve stimulation improve survival and reduce proinflammatory cytokines in mice with sepsis?
Transcutaneous vagus nerve stimulation improves survival and reduces inflammatory cytokines in a murine model of sepsis.
Huston et al. (2007) conducted an RCT in lethal endotoxemia or polymicrobial sepsis. Transcutaneous vagus nerve stimulation vs. sham or electrical vagus nerve stimulation was evaluated on survival and cytokine levels (TNF, HMGB1). Transcutaneous vagus nerve stimulation reduced systemic tumor necrosis factor and HMGB1 levels, and improved survival in mice with polymicrobial sepsis.
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