Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review

Figures

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  Figure 1.. Transesophageal echocardiogram presenting Stanford type A aortic dissection with intimal flap (left arrow).

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  Figure 2.. Computed tomography images of a 31-year-old female who sustained an acute Stanford Type A aortic dissection (A) prior to and (B) following surgery at 26 weeks of gestation.

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  Figure 3.. Sequencing peak map for the fibrillin-1 gene with pathogenic mutations. (A) Pathogenic mutation Exon 59, c. 7240 C > T (arrow) of the first patient. (B) Pathogenic mutation Exon 56, c.6725 G > A (arrow) of the second patient. (C) Exon 02, c. 12–27 (arrow) with the wild-type nucleotide from the 31-year-old female. (D) Pathogenic mutation Exon 02, c. 12–27 del GCGTCTGCTGGAGATC of the second patient; the position of base C (arrow) was the deletion starting point.

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  Figure 4.. Electrocardiogram presents a sinus rhythm with a rate of 115 beats/min and signs of ischaemic changes (the ST segment depression of lead I, II, avF and V1-V6 and ST segment elevation of lead avR).

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  Figure 5.. Sagittal (A) reconstructed and (B) standard CT images of a 32-year-old female patient who sustained an acute type A aortic dissection (DeBakey type II) at 34+1 weeks of gestation. The Sagittal reconstructed CT indicated that the aortic root was enlarged, and the size was 52 mm (left arrow). The standard CT indicated that the intimal flap (right arrow) was in the aortic root. CT, computed tomography.