Key result
This review details the current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of postural orthostatic tachycardia syndrome.
Why the study?
POTS is a heterogeneous disorder whose pathophysiology and mechanisms are not well understood, with multiple contributing factors and numerous potential mimics.
Answers are grounded in this paper and cite their sources.
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Other literature bears this out: a JACC focus seminar on POTS lists fibromyalgia among the most frequent nonorthostatic comorbidities, alongside chronic fatigue (up to 48%) and migraine, and proposes that POTS, ME/CFS, and FM may represent overlapping points on a shared dysautonomia-driven spectrum rather than distinct diseases.”
Provides a comprehensive overview of the pathophysiology, diagnosis, and management of Postural Orthostatic Tachycardia Syndrome (POTS).
Postural orthostatic tachycardia syndrome (POTS), the most common form of orthostatic intolerance in young people, affects approximately 500,000 people in the United States alone, typically young women at the peak of their education and the beginning of their working lives. This is a heterogeneous disorder, the pathophysiology and mechanisms of which are not well understood. There are multiple contributing factors and numerous potential mimics. This review details the most current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of POTS from cardiological and neurological perspectives.
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Bryarly et al. (2019) conducted a review in Postural orthostatic tachycardia syndrome (POTS). This review details the current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of postural orthostatic tachycardia syndrome.
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