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September 9, 2026Journal of the American College of Cardiology241 citationsOpen Access

Postural Orthostatic Tachycardia Syndrome

MBMeredith BryarlyLPLauren PhillipsQFQi Fu

Key Result

This review details the current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of postural orthostatic tachycardia syndrome.

Key Points

  • Synthesize current cardiological and neurological insights regarding the causes, subtypes, diagnostic evaluation, and management of postural orthostatic tachycardia syndrome.
  • Review of clinical evidence covering the pathophysiology, clinical mimics, and comorbid conditions associated with orthostatic intolerance.
  • Integration of diagnostic evaluations and therapeutic strategies across cardiology and neurology domains.
  • Characterizes postural orthostatic tachycardia syndrome as a complex disorder predominantly affecting approximately 500,000 young Americans, especially young women.
  • Identifies multifaceted contributing factors, distinct clinical subtypes, and frequent diagnostic mimics that complicate accurate evaluation and targeted therapy.

Structured PICO

P
Population
Young people, typically young women, with Postural Orthostatic Tachycardia Syndrome (POTS)

Provides a comprehensive overview of the pathophysiology, diagnosis, and management of Postural Orthostatic Tachycardia Syndrome (POTS).

Abstract

Postural orthostatic tachycardia syndrome (POTS), the most common form of orthostatic intolerance in young people, affects approximately 500,000 people in the United States alone, typically young women at the peak of their education and the beginning of their working lives. This is a heterogeneous disorder, the pathophysiology and mechanisms of which are not well understood. There are multiple contributing factors and numerous potential mimics. This review details the most current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of POTS from cardiological and neurological perspectives.

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Cite This Study

Bryarly et al. (2019) conducted a review in Postural orthostatic tachycardia syndrome (POTS). This review details the current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of postural orthostatic tachycardia syndrome.

synapsesocial.com/papers/6aa0d0183590e3d2c095fe7dhttps://doi.org/10.1016/j.jacc.2018.11.059
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