Key result
Rotavirus accounts for ~21% of acute gastroenteritis cases, driven primarily by the G9P[8] genotype.
Why the study?
Group A rotavirus infection is the leading cause of hospitalization in children under 5 years old presenting with acute gastroenteritis, prompting exploration of its genetic diversity in Moscow.
Cross-Sectional (n=653)
No
The study identifies a shift in rotavirus genotype prevalence in Moscow, including the first detection of Equine-like G3P[8] strains in Russia.
RVA surveillance data from Moscow may refine local epidemiology; leaves open generalizability and vaccine implications.
Group A rotavirus (RVA) infection is the leading cause of hospitalization of children under 5 years old, presenting with symptoms of acute gastroenteritis. The aim of our study was to explore the genetic diversity of RVA among patients admitted to Moscow Infectious Disease Clinical Hospital No. 1 with symptoms of acute gastroenteritis. A total of 653 samples were collected from May 2019 through March 2020. Out of them, 135 (20.67%) fecal samples were found to be positive for rotavirus antigen by ELISA. RT-PCR detected rotavirus RNA in 80 samples. Seven G-genotypes (G1, G2, G3, G4, G8, G9, and G12) and three P-genotypes (P[8], P[4], and P[6]) formed 9 different combinations. The most common combination was G9P[8]. However, for the first time in Moscow, the combination G3P[8] took second place. Moreover, all detected viruses of this combination belonged to Equine-like G3P[8] viruses that had never been detected in Russia before. The genotype G8P[8] and G9P[4] rotaviruses were also detected in Moscow for the first time. Among the studied rotaviruses, there were equal proportions of Wa and DS-1-like strains; previous studies showed that Wa-like strains accounted for the largest proportion of rotaviruses in Russia.
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Yuzhakov et al. (2021) conducted a cross-sectional in Acute gastroenteritis (n=653). Group A rotavirus (RVA) genotypes was evaluated on Rotavirus antigen positivity by ELISA.
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