Key result
Group A rotavirus was the most common viral pathogen detected among children aged <5 years (43.6%), whereas norovirus was most commonly detected in adults (11.9%).
Why the study?
What is the prevalence and genotype distribution of rotavirus and other viral agents in children and adults hospitalized with acute gastroenteritis in Russia?
Observational (n=4,562)
Yes
What is the prevalence and genotype distribution of rotavirus and other viral agents in children and adults hospitalized with acute gastroenteritis in Russia?
This multicenter surveillance study documents a significant burden of rotavirus disease among children hospitalized with acute gastroenteritis in Russia, highlighting the potential impact of vaccination.
May inform age-specific viral testing strategies; leaves open prospective validation before practice change.
During a 2-year period in 2005-2007, we conducted surveillance of group A rotaviruses and other enteric agents among patients hospitalized with acute gastroenteritis in 8 different cities of the Russian Federation. Fecal specimens were gathered from 3208 children (including 2848 children aged <5 years) and 1354 adults who were admitted to hospitals in Moscow, St. Petersburg, Chelyabinsk, Nizhnii Novgorod, Tyumen, Khabarovsk, Makhachkala, and Yakutsk. Polymerase chain reaction was performed to detect rotaviruses of groups A and C, noroviruses of genogroups I and II, astrovirus, sapovirus, and enteric adenoviruses (group F). Group A rotavirus was the most common viral pathogen detected among children aged <5 years (43.6%), followed by norovirus (12.5%), whereas norovirus was the pathogen most commonly detected in adults (11.9%). P and G genotypes were determined for 515 rotavirus specimens, and the most prevalent genotypes were G1P[8] (44.9%), G4P[8] (40.0%), G2P[4] (8.5%), and G3P[8] (6.6%). This study is the first multicenter study of rotaviruses in the Russian Federation and documents the important burden of disease caused by this pathogen, which soon may be preventable by vaccination.
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Подколзин et al. (2009) conducted an observational in Acute gastroenteritis (n=4,562). Viral enteric pathogens was evaluated on Detection of viral pathogens. Group A rotavirus was the most common viral pathogen detected among children aged <5 years (43.6%), whereas norovirus was most commonly detected in adults (11.9%).
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