Key result
Agonist-induced inhibition of TREK-2 via the M3 muscarinic receptor occurs primarily via PKC-mediated phosphorylation.
The inhibition of the TREK-2 potassium channel by Gq-coupled M3 muscarinic receptors is primarily mediated by PKC phosphorylation.
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May guide ion channel modulator development; hypothesis-generating for human cardiac translation.
Kang et al. (2006) studied this question. Acetylcholine (ACh) / M3 receptor activation was evaluated on Inhibition of TREK-2 whole cell current. Agonist-induced inhibition of TREK-2 via the M3 muscarinic receptor occurs primarily via PKC-mediated phosphorylation.
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