Key result
Female gender is linked to ~18% lower MACE risk versus men in advanced CKD.
Why the study?
Patients with CKD face increased MACE risk, but gender differences in this risk in older adults are not fully known.
Does female gender reduce the risk of MACE in older adults with advanced chronic kidney disease?
Population
Stage 4-5 CKD patients aged ≥65 years not on dialysis from six European countries
Comparison
Women vs men
Design
Prospective cohort study
Authors
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Comorbidity adjustment attenuates lower MACE risk in women with advanced CKD; leaves open independent sex effects for prospective study.
Cohort (n=1,736)
Yes
Does female gender reduce the risk of MACE in older adults with advanced chronic kidney disease?
Hazard Ratio: 0.82 (95% CI 0.69–0.97)
Absolute Event Rate: 31% vs 37%
p-value: p=0.02
In older adults with advanced CKD, women have a lower risk of MACE compared to men, which is partially explained by differences in pre-existing cardiometabolic comorbidities.
Astley et al. (2023) conducted a cohort in Advanced chronic kidney disease (stage 4-5) (n=1,736). Female gender vs. Male gender was evaluated on First major adverse cardiovascular event (MACE) (HR 0.82, 95% CI 0.69-0.97, p=0.02). Female gender was associated with an 18% lower risk of first major adverse cardiovascular events compared to men (HR 0.82) in older adults with advanced chronic kidney disease.
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