What question did this study set out to answer?

To review the progress in asthma genetics over the past 13 years and evaluate how genomic findings can identify new drug targets and guide therapeutic repurposing.

September 7, 2020The Lancet Respiratory MedicineOpen Access

The genetics of asthma and the promise of genomics-guided drug target discovery

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Authors

ZEZ. ElhusseiniBrigham and Women's Hospital RGReinoud GosensUniversity Medical Center Groningen FDFrank J. DekkerUniversity of Groningen

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Implication

Review uncovers 128 asthma-associated genetic loci in affected populations, highlighting new opportunities for genomics-guided drug target discovery and therapeutic repurposing.

Key Points

To review the progress in asthma genetics over the past 13 years and evaluate how genomic findings can identify new drug targets and guide therapeutic repurposing.
Synthesized findings from large-scale, well-powered asthma genetic association studies published over the past 13 years.
Evaluated 128 independent asthma risk loci to link genetic variants to underlying biological pathways and potential therapeutic targets.
Recent well-powered genetic studies expanded the catalog of independent asthma-associated genetic loci to 128.
Identified risk variants map to biological networks that pinpoint plausible molecular targets for developing new mechanism-based drugs or repurposing existing medications.

Cite This Study

Elhusseini et al. (2020) studied this question.

synapsesocial.com/papers/6aa0db5bb59423aee28d33ec https://doi.org/10.1016/s2213-2600(20)30363-5

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Implication

Review uncovers 128 asthma-associated genetic loci in affected populations, highlighting new opportunities for genomics-guided drug target discovery and therapeutic repurposing.

The genetics of asthma and the promise of genomics-guided drug target discovery

Discussion

Member takes

Implication

Key Points

Cite This Study

The genetics of asthma and the promise of genomics-guided drug target discovery

Discussion

Member takes

Implication

Key Points

Cite This Study

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