January 1, 2000Journal of Cardiovascular Pharmacology
Fundamental Electrophysiological Differences Between Low-Dose Intracoronary Endothelin-1 Infusion and Myocardial Ischemia Revealed By Multiple Monophasic Action Potential Recording
Key result
Intracoronary endothelin-1 prolongs action potential and increases dispersion, supporting a direct arrhythmogenic effect.
- P<0.05
- n=26
Why the study?
Does intracoronary endothelin-1 infusion cause direct arrhythmogenic electrophysiological changes compared to myocardial ischemia in a canine model?
Population
Canine model (n=26)
Comparison
Intracoronary endothelin-1 infusion at 30… vs 30 min left anterior descending artery occlusion…
Design
Preclinical
Follow-up
90 minutes (30 min intervention + 60 min reperfusion)
Authors
Discussion
Loading...
Member takes
Implication
Endothelin-1 may promote arrhythmias via direct effects independent of ischemia in canines; leaves open human translation and therapeutic relevance.
Structured PICO
Does intracoronary endothelin-1 infusion cause direct arrhythmogenic electrophysiological changes compared to myocardial ischemia in a canine model?
P
Population
26 dogs in a canine model evaluating electrophysiological changes during LAD occlusion and intracoronary ET-1 infusion.
I
Intervention
Intracoronary endothelin-1 (ET-1) infusion at 30 pmol/min (n=8) or 60 pmol/min (n=10)
C
Comparator
30 min left anterior descending artery (LAD) occlusion followed by 60 min reperfusion (n=8)
O
Outcome
Changes in monophasic action potential duration (MAPD90), monophasic action potential dispersion (MAPDISP), and upstroke velocity (UV)surrogate
Main Result
p-value: p=<0.05
Endothelin-1 exerts direct arrhythmogenic effects independent of ischemia, characterized by action potential prolongation, increased dispersion, and early afterdepolarizations.
Cite This Study
Gellér et al. (2000) studied Myocardial ischemia and arrhythmogenesis (n=26). Intracoronary endothelin-1 (ET-1) infusion vs. LAD occlusion was evaluated on Changes in monophasic action potential duration (MAPD90), dispersion (MAPDISP), and upstroke velocity (UV) (p=<0.05). Intracoronary endothelin-1 infusion prolonged monophasic action potential, increased dispersion, and caused early afterdepolarizations, supporting a direct arrhythmogenic effect.