January 1, 1998Pacing and Clinical Electrophysiology
Electrophysiological Effects of Intrapericardial Infusion of Endothelin‐1
Why the study?
Does intrapericardial infusion of endothelin-1 induce ventricular arrhythmias in anesthetized dogs?
Population
Anesthetized dogs (n=15)
Comparison
Intrapericardial infusion of endothelin-1 at… vs Control animals (n=3)
Design
Preclinical
Follow-up
40 min
Authors
Discussion
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Member takes
Implication
May implicate ET-1 in ventricular arrhythmogenesis; leaves open translation to human disease.
Structured PICO
Does intrapericardial infusion of endothelin-1 induce ventricular arrhythmias in anesthetized dogs?
P
Population
Anesthetized dogs (n=15)
I
Intervention
Intrapericardial infusion of endothelin-1 (ET-1) at 0.125-1.0 nmol/min for 40 min
C
Comparator
Control animals (n=3)
O
Outcome
Induction of ventricular tachyarrhythmias and changes in electrophysiological parameters (QT interval, MAP duration)surrogate
Intrapericardial administration of endothelin-1 induces ventricular arrhythmias in dogs, likely through prolongation of action potential duration and development of afterdepolarizations.
Limitations
- Elucidation of the precise mechanism needs further investigation
Cite This Study
Gellér et al. (1998) studied this question.