January 1, 1995Journal of Cardiovascular Pharmacology
Ventricular Tachycardias Induced by Intracoronary Administration of Endothelin-1 in Dogs
Key result
Intracoronary endothelin-1 infusion in dogs induced fatal ventricular arrhythmias, including ventricular fibrillation in 11 of 12 cases, and significantly prolonged QT time (P<0.05).
Why the study?
Does intracoronary endothelin-1 induce ventricular arrhythmias in a canine model?
Population
12 anesthetized, open-chest mongrel dogs
Design
Preclinical
Follow-up
30-40 minutes
Authors
Discussion
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Implication
Endothelin-1 may promote fatal arrhythmias in coronary ischemia; leaves open translation from canine models to human therapeutics.
Structured PICO
Does intracoronary endothelin-1 induce ventricular arrhythmias in a canine model?
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Population
12 anesthetized, open-chest mongrel dogs undergoing intracoronary endothelin-1 infusion and electrophysiologic studies.
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Intervention
Endothelin-1 (ET-1) infused into the left anterior descending coronary artery (30 pmol/min for 30 min in n=8; increased to 60 pmol/min for 10 min in n=4)
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Outcome
Ventricular arrhythmias and electrophysiologic changes (QT time)surrogate
Main Result
p-value: p=<0.05
Intracoronary endothelin-1 induces fatal ventricular arrhythmias and QT prolongation in a canine model, an effect that appears at least partly independent of its vasoconstrictor properties.
Cite This Study
Tóth et al. (1995) studied Ventricular arrhythmias (n=12). Endothelin-1 (ET-1) was evaluated on QT time and ventricular arrhythmias (p=<0.05). Intracoronary endothelin-1 infusion in dogs induced fatal ventricular arrhythmias, including ventricular fibrillation in 11 of 12 cases, and significantly prolonged QT time (P<0.05).