Key result
Intrapericardial infusion of exogenous endothelin-1 induced ventricular arrhythmias in 100% of dogs compared to 0% with saline, and significantly prolonged QT time and MAP duration.
Why the study?
Does intrapericardial infusion of endothelin-1 induce ventricular arrhythmias in anesthetized dogs?
Does intrapericardial infusion of endothelin-1 induce ventricular arrhythmias in anesthetized dogs?
Absolute Event Rate: 100% vs 0%
Intrapericardial infusion of endothelin-1 in dogs induces ventricular arrhythmias and prolongs repolarization, suggesting a potential arrhythmogenic role for high pericardial ET-1 levels.
No takes yet. Share an insight, caveat, or question.
Suggests pericardial ET-1 arrhythmogenicity in dogs; leaves open translation to human ventricular arrhythmias or therapies.
István Szokodi (1998) studied Ventricular arrhythmias (n=17). Endothelin-1 (ET-1) vs. Physiological saline was evaluated on Ventricular arrhythmias. Intrapericardial infusion of exogenous endothelin-1 induced ventricular arrhythmias in 100% of dogs compared to 0% with saline, and significantly prolonged QT time and MAP duration.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: