Key result
Depression linked to CVD via serotonin, platelets, immune pathways, and female sex differences.
This review explores the pathophysiological mechanisms linking depression and cardiovascular disease, with a specific focus on serotonin, platelets, immune function, and sex differences.
Highlights sex-specific mechanisms in depression-CVD; leaves open targeted interventions pending prospective trials.
The comorbidity of cardiovascular disease (CVD) and depression/anxiety disorders is well established, but the mechanisms are not well understood. This paper will review the epidemiological and biological evidence for the role of depression in CVD, as well as the pathophysiological process underlying both depression and CVD. The focus will be on the roles of serotonin, platelets, and the immune system, with an emphasis on the relevance of sex differences in both depression/anxiety and CVD as they pertain to women.
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Meir Steiner (2011) conducted a review in Cardiovascular disease and depression/anxiety disorders. Depression was evaluated. This review examines the epidemiological and biological evidence linking depression and cardiovascular disease, focusing on serotonin, platelets, the immune system, and sex differences in women.
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