Key result
Oral alprazolam 0.5 mg was as effective as captopril 25 mg in lowering systolic blood pressure over 2 hours in emergency department patients with initial SBP ≥ 160 mmHg.
Why the study?
Does oral alprazolam 0.5 mg reduce blood pressure as effectively as oral captopril 25 mg in emergency department patients with acute asymptomatic blood pressure elevation (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg)?
Population
n=53 Emergency department patients with an initial systolic BP ≥ 160 mmHg or diastolic BP ≥ 100 mmHg but no…
Comparison
Oral alprazolam 0.5 mg vs Oral captopril 25 mg
Design
RCT, Randomly assigned
Follow-up
2 hours
Authors
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Alprazolam matches captopril for acute BP reduction in ED hypertensive urgency; extends options beyond conventional antihypertensives.
RCT (n=53)
Randomly assigned
Does oral alprazolam 0.5 mg reduce blood pressure as effectively as oral captopril 25 mg in emergency department patients with acute asymptomatic blood pressure elevation (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg)?
Alprazolam 0.5 mg is as effective as captopril 25 mg in acutely lowering blood pressure over 2 hours in emergency department patients with severe asymptomatic hypertension.
Yılmaz et al. (2011) conducted an RCT in High blood pressure / Anxiety (n=53). Alprazolam vs. Captopril 25 mg oral was evaluated on Change in systolic blood pressure and anxiety levels (VAS-A). Oral alprazolam 0.5 mg was as effective as captopril 25 mg in lowering systolic blood pressure over 2 hours in emergency department patients with initial SBP ≥ 160 mmHg.
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