What question did this study set out to answer?

To evaluate the influence of pulsed electromagnetic fields on the repopulation kinetics of damaged endothelial monolayers and the assembly of cells into complex vessel structures.

January 1, 1988Journal of Cellular Physiology

Endothelial cell response to pulsed electromagnetic fields: Stimulation of growth rate and angiogenesis in vitro

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Authors

GYG. P. Ameia Yen‐PattonHarvard University WPWayne F. PattonState University of New York at Potsdam BJBruce S. JacobsonUniversity of Massachusetts Amherst

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Implication

In vitro study demonstrates enhanced proliferation and rapid vessel formation in endothelial cell cultures exposed to pulsed electromagnetic fields, indicating potential for tissue regeneration.

Key Points

To evaluate the influence of pulsed electromagnetic fields on the repopulation kinetics of damaged endothelial monolayers and the assembly of cells into complex vessel structures.
Monitored partially denuded monolayers of human umbilical vein and bovine aortic endothelial cells exposed to pulsed electromagnetic fields using tritiated thymidine incorporation.
Assessed three-dimensional capillary-like structure reorganization following complete enzymatic disruption with EDTA-trypsin in cultures supplemented with heparin, endothelial cell growth factor, and fibronectin.
Pulsed electromagnetic field exposure stimulated a statistically significant 20% to 40% enhancement in endothelial monolayer repopulation growth rate relative to unexposed controls.
Migrating cells exposed to the field adopted an elongated, sprouting morphology connecting end-to-end, differing from the cuboidal shape seen in control cultures.
Disrupted endothelial cells reorganized into three-dimensional vessel-like networks within 5 to 8 hours under field exposure, whereas unexposed cultures showed no vascularization.

Cite This Study

Yen‐Patton et al. (1988) studied this question.

synapsesocial.com/papers/6aa0e2285c6473af29f7a2d1 https://doi.org/10.1002/jcp.1041340105

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Implication

In vitro study demonstrates enhanced proliferation and rapid vessel formation in endothelial cell cultures exposed to pulsed electromagnetic fields, indicating potential for tissue regeneration.

Endothelial cell response to pulsed electromagnetic fields: Stimulation of growth rate and angiogenesis in vitro

Discussion

Member takes

Implication

Key Points

Cite This Study

Endothelial cell response to pulsed electromagnetic fields: Stimulation of growth rate and angiogenesis in vitro

Discussion

Member takes

Implication

Key Points

Cite This Study

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