April 29, 2016American Journal of Medical Genetics Part A
Pregnancy after aortic root replacement in Loeys–Dietz syndrome: High risk of aortic dissection
Key result
Pregnancy after Loeys-Dietz aortic root replacement is linked to ~67% postpartum dissection risk.
- n=3
Why the study?
What is the risk of aortic dissection during or after pregnancy in women with Loeys-Dietz syndrome who have undergone prior aortic root replacement?
Population
3 women with Loeys-Dietz syndrome who underwent elective aortic root replacement for aneurysm disease and…
Design
Case_series
Follow-up
postpartum period
Authors
Discussion
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Implication
Pregnancy in Loeys-Dietz syndrome carries aortic and uterine risks; leaves open optimal counseling and management strategies.
Study Design
Type
Case Report (n=3)
Structured PICO
What is the risk of aortic dissection during or after pregnancy in women with Loeys-Dietz syndrome who have undergone prior aortic root replacement?
P
Population
3 women with Loeys-Dietz syndrome who became pregnant after elective aortic root replacement and were followed through the postpartum period.
E
Exposure
Pregnancy (managed with beta blockers throughout and Cesarean section delivery)
O
Outcome
Acute aortic dissection in the postpartum periodhard clinical
Pregnancy following aortic root replacement in Loeys-Dietz syndrome carries a high risk of postpartum acute aortic dissection, highlighting the need for careful counseling.
Cite This Study
Braverman et al. (2016) conducted a case report in Loeys-Dietz syndrome (n=3). Pregnancy after aortic root replacement was evaluated on Acute aortic dissection. Pregnancy following aortic root replacement in Loeys-Dietz syndrome resulted in acute aortic dissection in the postpartum period in 2 of 3 women (66.7%).