Key result
Cesarean delivery at 36 weeks yields no cardiovascular complications in a Loeys-Dietz syndrome patient.
Why the study?
Pregnancy may increase the risk of aortic dissection in women with Loeys-Dietz syndrome, necessitating specialized obstetric management.
Case Report (n=1)
Multidisciplinary obstetric management, including planned cesarean delivery, can be safely performed in patients with Loeys-Dietz syndrome to mitigate the risk of aortic dissection.
May inform delivery planning in Loeys-Dietz pregnancies; leaves open need for prospective aortic risk data.
BACKGROUND: Loeys-Dietz syndrome is associated with arterial tortuosity and aortic dissection. Pregnancy may be a period of increased risk for aortic dissection. CASE: A 16-year-old primigravid girl was referred to our center with a family history of aortic dissection. Loeys-Dietz syndrome was suspected, and genetic testing confirmed the TGFβ2 (c.988C>T) mutation. A cesarean delivery was performed at 36 weeks of gestation, with no cardiovascular complications. In this case, the uterine vessels were significantly tortuous; this may be an additional finding in Loeys-Dietz syndrome. CONCLUSION: Women with Loeys-Dietz syndrome warrant special consideration in obstetric management secondary to the risk for aortic dissection. It is recommended that a multidisciplinary team with knowledge about connective tissue disorders and expertise in aortic surgery coordinate maternal obstetric and cardiovascular care.
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Russo et al. (2018) conducted a case report in Loeys-Dietz syndrome in pregnancy (n=1). Cesarean delivery was evaluated on Cardiovascular complications. Cesarean delivery at 36 weeks of gestation in a 16-year-old with Loeys-Dietz syndrome was performed with no cardiovascular complications, revealing significantly tortuous uterine vessels.