Key result
Type I diabetic patients with microalbuminuria or albuminuria had increased mass concentrations of highly atherogenic intermediate-density lipoproteins compared to normoalbuminuric patients (P<0.05).
Observational (n=209)
p-value: p=<0.05
Type I diabetic patients with early renal disease exhibit multiple potentially atherogenic lipoprotein changes, including increased intermediate-density lipoproteins, which may contribute to excess macrovascular complications.
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Hypothesis-generating for IDL contribution to macrovascular risk in type 1 diabetes with albuminuria; prospective studies needed before practice implications.
Groop et al. (1996) conducted an observational in Type I diabetes with renal disease (n=209). Elevated albumin excretion rate (microalbuminuria and albuminuria) vs. Normoalbuminuria and healthy controls was evaluated on Mass concentrations of intermediate-density lipoprotein fraction (p=<0.05). Type I diabetic patients with microalbuminuria or albuminuria had increased mass concentrations of highly atherogenic intermediate-density lipoproteins compared to normoalbuminuric patients (P<0.05).
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