Key result
Persistent microalbuminuria in type 1 diabetes is linked to lower HDL cholesterol.
Why the study?
Differences in serum lipid and lipoprotein concentrations between insulin-dependent diabetic patients with persistent microalbuminuria and those with normal albumin excretion were unclear.
Are serum lipid and lipoprotein concentrations altered in insulin-dependent diabetic patients with persistent microalbuminuria compared to those with normal albumin excretion?
Population
18 insulin-dependent diabetic patients with persistent microalbuminuria and 18 matched with normal albumin excretion
Comparison
Diabetic patients with persistent microalbuminuria vs diabetic patients with normal albumin excretion and non-diabetic subjects
Design
Observational matched case-control study
Authors
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Atherogenic lipid changes associated with microalbuminuria in diabetes; hypothesis-generating for cardiovascular risk and requires prospective confirmation.
Observational
Are serum lipid and lipoprotein concentrations altered in insulin-dependent diabetic patients with persistent microalbuminuria compared to those with normal albumin excretion?
Mean Difference: 0.29 (95% CI 0.12–0.46)
p-value: p=<0.01
Insulin-dependent diabetic patients with persistent microalbuminuria exhibit an atherogenic lipid profile characterized by lower HDL and a higher LDL:HDL ratio, which may contribute to increased cardiovascular risk.
Watts et al. (1989) conducted an observational in Insulin-dependent diabetes. Persistent microalbuminuria vs. Persistently normal albumin excretion was evaluated on High density lipoprotein (HDL) cholesterol concentration (difference 0.29 mmol/L, 95% CI 0.12 to 0.46, p=<0.01). Insulin-dependent diabetic patients with persistent microalbuminuria had significantly lower HDL cholesterol (difference 0.29 mmol/L; 95% CI 0.12-0.46; p<0.01) than those with normal albumin excretion.
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