Key result
Removing Mannitol and Voluven from cardiopulmonary bypass priming fluid did not adversely affect fluid balance or electrolytes, and significantly reduced the proportion of ICU time spent on mechanical ventilation (22.6% vs 31.5%, p=0.022).
Why the study?
Does removing mannitol and hydroxyethyl starch from cardiopulmonary bypass priming fluid affect fluid balance and clinical outcomes in patients undergoing isolated CABG?
Population
100 consecutive patients undergoing primary, isolated coronary artery bypass grafting
Comparison
Plasma-lyte-based cardiopulmonary bypass priming… vs Plasma-lyte-based cardiopulmonary bypass priming…
Design
Cohort
Follow-up
Postoperative/hospital stay
Authors
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No detrimental effects observed after removing mannitol and voluven from CPB prime; leaves open whether this simplifies priming safely across procedures.
Cohort (n=100)
No
Does removing mannitol and hydroxyethyl starch from cardiopulmonary bypass priming fluid affect fluid balance and clinical outcomes in patients undergoing isolated CABG?
Absolute Event Rate: 22.6% vs 31.5%
p-value: p=0.022
Removing mannitol and hydroxyethyl starch from cardiopulmonary bypass priming fluid is safe, does not adversely affect fluid balance or electrolytes, and may offer economic benefits.
Haydock et al. (2014) conducted a cohort in Coronary artery disease requiring CABG (n=100). Cardiopulmonary bypass priming fluid without Mannitol and Voluven vs. Cardiopulmonary bypass priming fluid with Mannitol and Voluven was evaluated on Percentage of time in ICU on mechanical ventilation (p=0.022). Removing Mannitol and Voluven from cardiopulmonary bypass priming fluid did not adversely affect fluid balance or electrolytes, and significantly reduced the proportion of ICU time spent on mechanical ventilation (22.6% vs 31.5%, p=0.022).
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