Key result
Removing Mannitol and Voluven from cardiopulmonary bypass priming fluid increased mean arterial pressure on bypass (61.5 vs 57.5 mmHg, p=0.002) without detrimental effects on clinical outcomes.
Why the study?
Does removing Mannitol and Voluven from the priming fluid of the cardiopulmonary bypass circuit improve fluid balance and clinical outcomes in patients undergoing primary isolated CABG?
Population
100 consecutive patients undergoing primary, isolated coronary artery bypass grafting (CABG)
Comparison
Plasma-lyte-based cardiopulmonary bypass priming… vs Plasma-lyte-based cardiopulmonary bypass priming…
Design
Cohort
Follow-up
Postoperative/hospital stay
Authors
Loading...
Retrospective CPB prime change audit is hypothesis-generating; leaves open effects on fluid balance and outcomes.
Observational (n=100)
No
Does removing Mannitol and Voluven from the priming fluid of the cardiopulmonary bypass circuit improve fluid balance and clinical outcomes in patients undergoing primary isolated CABG?
Absolute Event Rate: 61.5% vs 57.5%
p-value: p=0.002
Removing Mannitol and Voluven from CPB priming fluid during CABG is safe, does not worsen clinical outcomes, and may reduce the proportion of ICU time spent on mechanical ventilation.
Haydock et al. (2014) conducted an observational in Primary, isolated coronary artery bypass grafting (CABG) (n=100). Removal of Mannitol and Voluven from CPB priming fluid vs. CPB priming fluid containing Mannitol and Voluven was evaluated on Mean arterial pressure while on bypass (p=0.002). Removing Mannitol and Voluven from cardiopulmonary bypass priming fluid increased mean arterial pressure on bypass (61.5 vs 57.5 mmHg, p=0.002) without detrimental effects on clinical outcomes.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: