Key result
Mannitol included in the cardiopulmonary bypass prime significantly increased diuresis by 12 hours in the ICU compared to control (p=0.001).
Why the study?
Does mannitol in the cardiopulmonary bypass priming solution improve diuresis in patients undergoing open-heart surgery?
Population
76 human patients undergoing open-heart surgery with cardiopulmonary bypass
Comparison
Mannitol included in the priming solution of the… vs Control group who did not receive mannitol in…
Design
Cohort
Follow-up
12 hours in the intensive care unit
Authors
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Should not yet change CPB priming practice; leaves open need for RCTs to confirm renal benefit.
Does mannitol in the cardiopulmonary bypass priming solution improve diuresis in patients undergoing open-heart surgery?
p-value: p=0.001
Including mannitol in the cardiopulmonary bypass priming solution significantly increases postoperative diuresis, suggesting a potential amelioration of ischemic effects on the kidneys.
Fisher et al. (1998) studied Open-heart surgery with cardiopulmonary bypass (n=76). Mannitol vs. No mannitol was evaluated on Diuresis (p=0.001). Mannitol included in the cardiopulmonary bypass prime significantly increased diuresis by 12 hours in the ICU compared to control (p=0.001).
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