Key result
Mannitol administered before aortic cross-clamping reduced postoperative urinary albumin (160 vs 500 mg/mmol creatinine; P=0.036) compared to saline, indicating reduced subclinical renal injury.
Why the study?
Does mannitol reduce renal reperfusion injury in patients undergoing infrarenal aortic aneurysm repair?
RCT (n=28)
Does mannitol reduce renal reperfusion injury in patients undergoing infrarenal aortic aneurysm repair?
Absolute Event Rate: 160% vs 500%
p-value: p=0.036
Mannitol administration before aortic cross-clamping reduces subclinical glomerular and renal tubular damage during infrarenal aortic aneurysm repair.
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Supports mannitol before aortic cross-clamping in AAA repair; confirms renoprotection in this RCT setting.
Tisi et al. (1997) conducted an RCT in infrarenal aortic aneurysm (n=28). Mannitol vs. Saline was evaluated on postoperative levels of urinary albumin (mg per mmol creatinine) (p=0.036). Mannitol administered before aortic cross-clamping reduced postoperative urinary albumin (160 vs 500 mg/mmol creatinine; P=0.036) compared to saline, indicating reduced subclinical renal injury.
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