Does the administration of mannitol prevent renal failure in open abdominal aortic aneurysm surgery?

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Why the study?

Does mannitol administration prevent renal failure in patients undergoing open repair of an abdominal aortic aneurysm?

Structured PICO

Does mannitol administration prevent renal failure in patients undergoing open repair of an abdominal aortic aneurysm?

Population

319 patients undergoing open repair of an abdominal aortic aneurysm (pooled from 8 studies)

Intervention

Mannitol administration

Outcome

Renal failure (with earlier studies using urine output as the main indicator)hard clinical

Current evidence does not support the use of mannitol to prevent renal failure during open abdominal aortic aneurysm repair.

Five of the eight included studies date from 1961-1965 with low level of evidence (3b or 4)
Earlier studies used urine output as their main indicator of renal failure

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Does not support mannitol for renal protection in open AAA repair; challenges routine use and leaves open need for effective alternatives.

Hersey et al. (2008) studied this question.

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Does not support mannitol for renal protection in open AAA repair; challenges routine use and leaves open need for effective alternatives.