Key result
Administration of measles antibody after virus inoculation in mice abolished acute fatal encephalopathy (80% mortality) but induced subacute encephalitis with 30% mortality and viral persistence.
Why the study?
Does measles antibody administration after virus inoculation induce viral persistence and subacute encephalitis in Balb/c mice?
Case Report
Does measles antibody administration after virus inoculation induce viral persistence and subacute encephalitis in Balb/c mice?
Antibody transfer during viral infection can induce viral persistence and subacute encephalitis, suggesting caution in human prophylaxis with immune globulin.
Answers are grounded in this paper and cite their sources.
Antibody post-inoculation may induce subacute encephalitis and viral persistence in this model; hypothesis-generating and should not yet change human practice.
Subacute sclerosing panencephalitis (SSPE) developed in a patient in whom natural measles infection was anteceded by immunization with measles immune serum globulin (ISG). This observation prompted experimental studies of the role of antibody in viral persistence. When Balb/c mice were infected with the hamster neurotropic measles virus, acute encephalopathy was fatal in 80% of the animals. When measles antibody was administered 3 days after virus inoculation, the acute disease was abolished and subacute encephalitis had a 30% mortality. The subacute disease was characterized by the presence of neuronal viral antigen, meningitis, and encephalitis. Induction of viral persistence was therefore a consequence of antibody transfer during viral infection. Caution is advised in human prophylaxis with immune globulin.
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Rammohan et al. (1982) conducted a case report in Subacute sclerosing panencephalitis (SSPE). Measles immune serum globulin (ISG) / measles antibody vs. No antibody (in mice) was evaluated on Mortality. Administration of measles antibody after virus inoculation in mice abolished acute fatal encephalopathy (80% mortality) but induced subacute encephalitis with 30% mortality and viral persistence.
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