Effect of Intraoperative Goal-directed Fluid Therapy on the Postoperative Brain Edema in Patients undergoing High-Grade Gliomas Resections: a study protocol of randomized control trial

Introduction Brain edema is the most frequent postoperative complication after brain tumor resection, especially in patients with high-grade glioma. However, the effect of SVV-based goal-directed fluid therapy (GDFT) on postoperative brain edema and the prognosis remain unclear. Methods and analysis This is a prospective, randomized, double-blinded, parallel-controlled trial aiming to observe whether stroke volume variation (SVV)-based GDFT could improve the postoperative brain edema in patients undergoing supratentorial high-grade gliomas compared with traditional fluid therapy. The patient will be given 3mL/kg hydroxyethyl starch solution when the SVV is greater than 15% continously for more than 5 minutes intraoperatively. The primary outcome will be postoperative cerebral edema volume on brain CT within 24 hours. Ethics and dissemination This trial has been registered at ClinicalTrial.gov (NCT03323580) and approved by the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (reference number: KY2017-067-02). The findings will be disseminated in peer-reviewed journals and presented at national or international conferences relevant to subject fields. Trial registration number NCT03323580.