Key result
Baseline IL-6 levels were significantly associated with depressive symptoms 7 months after myocardial infarction (β = .57, p < .01).
Why the study?
Are baseline inflammatory markers associated with future depressive symptoms in patients with acute myocardial infarction?
Cohort
Are baseline inflammatory markers associated with future depressive symptoms in patients with acute myocardial infarction?
Effect estimate: β = .57
p-value: p=<.01
Baseline IL-6 levels in MI patients are prospectively associated with depressive symptoms 7 months post-discharge, highlighting a temporal relationship between inflammation and post-MI depression.
Should not yet change post-MI care; leaves open whether IL-6 predicts or drives depressive symptoms.
Inflammatory activity has been associated with both coronary disease and depressive symptoms. We sought to determine whether inflammatory markers in myocardial infarction (MI) patients are prospectively associated with depressive symptomatology. Participants were a convenience sample of MI patients. Depressive symptoms were assessed soon after the MI and again 7 months postdischarge. Inflammatory markers examined were interleukin‐6 (IL‐6) and interleukin‐1β. Results suggest no significant cross‐sectional association between inflammatory markers and depressive symptoms at baseline. However, bivariate and multiple regression analyses revealed a significant positive prospective association between baseline IL‐6 and depressive symptoms 7 months later (β = .57, p < .01). The results suggest that temporal considerations are important in understanding relationships between inflammation and depressive symptoms following MI.
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Hekler et al. (2007) conducted a cohort in Acute Myocardial Infarction. Baseline inflammatory markers (IL-6 and IL-1β) was evaluated on Depressive symptoms at 7 months postdischarge (β = .57, p=<.01). Baseline IL-6 levels were significantly associated with depressive symptoms 7 months after myocardial infarction (β = .57, p < .01).
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