Preconceptions About Vaccination Against Paralytic Poliomyelitis

Article1 April 1959PRECONCEPTIONS ABOUT VACCINATION AGAINST PARALYTIC POLIOMYELITISJONAS E. SALK, M.D.JONAS E. SALK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-4-843 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen one reflects upon the growing evidence that a killed-virus vaccine is likely to bring about the control of paralytic polio, there comes to mind the definition of science quoted by Gustafson1 as that body of knowledge obtained by technics that enable us to place limiting values on our preconceptions.I recall the general statement I first heard more than 20 years ago—that immunity to a virus disease had not been, or could not be, induced by a killed-viral antigen. Less than a decade ago (and, in some quarters, today), the more acceptable view was that the control of polio,...Bibliography1. Gustavson RG: Pitcairn-Crabbe Lecture, University of Pittsburgh, Spring, 1958. Google Scholar2. Salk JE: Considerations in the preparation and use of poliomyelitis virus vaccine, J. A. M. A. 158: 1239, 1955. CrossrefMedlineGoogle Scholar3. Salk JE: How many injections of poliomyelitis vaccine for effective and durable immunity?, J. A. M. A. 167: 1, 1958. CrossrefMedlineGoogle Scholar4. Salk JE: Antigenic potency of poliomyelitis vaccine, J. A. M. A. 162: 1451, 1956. CrossrefMedlineGoogle Scholar5. Salk JE: Requirements for persistent immunity to poliomyelitis, Tr. A. Am. Physicians 69: 105, 1956. MedlineGoogle Scholar6. Salk JE: A concept of the mechanism of immunity for preventing paralysis in poliomyelitis, Ann. New York Acad. Sc. 61: 1023, 1955. CrossrefMedlineGoogle Scholar7. Sabin AB: Properties of attenuated polioviruses and their behavior in human beings, N. Y. Acad. Sc. Spec. Pub., 5, 113. Google Scholar8. FoxGelfandBhattLeblancConwell JPHMPNDRDP: Immunizing infections with poliomyelitis viruses and sero-immune patterns in southern Louisiana, Ann. New York Acad. Sc. 61: 968, 1955. CrossrefMedlineGoogle Scholar9. WehrleReichertCarbonaroPortnoy PFROB: Influence of prior active immunization on the presence of poliovirus in the pharynx and stools of family contacts of polio cases, Pediatrics 21: 353, 1958. MedlineGoogle Scholar10. Howe HA (a) : Studies of active immunogenesis in poliomyelitis. I. Persistence and recall by homotypic or heterotypic superinfection of neutralizing antibody originally induced in chimpanzees by vaccination or infection, Am. J. Hyg. 60: 371, 1954. (b) Howe, H. A.: Studies of active immunogenesis in poliomyelitis. II. Lack of immunity in chimpanzees receiving formol-inactivated vaccines of marginal antigenic potency, Am. J. Hyg. 60: 392, 1954. (c) Howe, H. A., with the technical assistance of O'Leary, W., Bender, W., Kiel, M., and Fontanella, A.: Day by day response of vaccinated chimpanzees to poliomyelitis infection, Am. J. Pub. Health 47: 871, 1957. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Received for publication August 15, 1958.Presented as the James D. Bruce Memorial Lecture at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 30, 1958.Aided by a grant from The National Foundation for Infantile Paralysis.Requests for reprints should be addressed to Jonas E. Salk, M.D., Virus Research Laboratory University of Pittsburgh School of Medicine, Terrace and Darragh Streets, Pittsburgh 13, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntestinal immunity following a combined enhanced inactivated polio vaccine/oral polio vaccine programme in IsraelInactivated and live, attenuated poliovirus vaccines: mucosal immunityVaccinology of poliomyelitisVaccination against poliomyelitisPrinciples of Vaccinology in the Control of Virus Diseases: PoliomyelitisControl of Influenza and Poliomyelitis with Killed Virus VaccinesVaccination against PoliomyelitisVaccination against poliomyelitisPERSISTENCE OF IMMUNITY AFTER ADMINISTRATION OF FORMALIN-TREATED POLIOVIRUS VACCINEIMMUNIZATIONF. R. MCCRUMB JR., M.D.Poliomyelitis VaccinesVaccination Against Poliomyelitis: an Ounce of Prevention 1 April 1959Volume 50, Issue 4Page: 843-861KeywordsAntigensEpidemiologyImmunityPoliomyelitisVaccines ePublished: 1 December 2008 Issue Published: 1 April 1959 Copyright & PermissionsCopyright ©, 1959, by The American College of PhysiciansPDF downloadLoading ...