Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 1942Annals of Internal Medicine

Intracutaneous Inoculation of Poliomyelitis Virus in Monkeys and Its Detection in Their Stools

View Full Paper
Ask AI
Bookmark
Share

Key result

Intracutaneous inoculation of poliomyelitis virus was performed in 11 primates to determine if the virus could be detected in their stools.

Population

10 monkeys representing four (or five) different species and one chimpanzee

Design

Preclinical

Authors

JTJames D. TraskYale New Haven HospitalJPJohn R. PaulChristian Medical College, Vellore

Discussion

Loading...

Member takes

Implication

Animal model data on polio stool detection remain preliminary; leaves open human transmission or diagnostic relevance.

Structured PICO

P
Population
11 primates (10 monkeys and 1 chimpanzee) inoculated intracutaneously with poliomyelitis virus to detect the virus in their stools.
I
Intervention
Intracutaneous inoculation with the SK strain of poliomyelitis virus (generation XIV) in 10 piqures in the left flank with 2 c.c. of a 10 per cent suspension of glycerolated cord
O
Outcome
Detection of poliomyelitis virus in stoolssurrogate

This preclinical study investigated whether the poliomyelitis virus could be detected in the stools of non-human primates following intracutaneous inoculation.

Cite This Study

Trask et al. (1942) studied Poliomyelitis (n=11). Intracutaneous inoculation of poliomyelitis virus (SK strain) was evaluated on Detection of poliomyelitis virus in stools. Intracutaneous inoculation of poliomyelitis virus was performed in 11 primates to determine if the virus could be detected in their stools.

synapsesocial.com/papers/6a96ad3e132cd8a75e579469https://doi.org/10.7326/0003-4819-17-6-975
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DETECTION OF THE VIRUS OF POLIOMYELITIS IN THE NOSE AND THROAT AND GASTRO-INTESTINAL TRACT OF HUMAN BEINGS AND MONKEYS1939 · 44 citations
  2. 2RESPIRATORY VERSUS GASTRO-INTESTINAL INFECTION IN POLIOMYELITIS1936 · 37 citations
  3. 3PERSISTENCE OF THE VIRUS OF POLIOMYELITIS IN THE NASOPHARYNX1919 · 13 citations
  4. 4LOCALIZATION OF THE VIRUS AND PATHOGENESIS OF EPIDEMIC POLIOMYELITIS1914 · 37 citations
  5. 5ISOLATION OF POLIOMYELITIS VIRUS FROM THE NASOPHARYNX1935 · 25 citations