Increased plasma viscosity and erythrocyte aggregation: indicators of an unfavourable clinical outcome in patients with unstable angina pectoris.
Key result
Increased plasma viscosity linked to ~6-fold higher MI risk in unstable angina.
- OR 6.1
- 95% CI 1.3 to 31
- P=0.008
- n=96
Why the study?
Do increased plasma viscosity and erythrocyte aggregation predict myocardial infarction in patients with unstable angina?
Population
96 consecutive patients with unstable angina
Comparison
Plasma viscosity ≥ 1.38 mPa s and/or rate… vs Plasma viscosity < 1.38 mPa s and/or erythrocyte…
Design
Cohort
Follow-up
six months or until angioplasty or bypass surgery
Authors
Discussion
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Member takes
Implication
Elevated plasma viscosity may aid risk stratification in unstable angina; leaves open whether viscosity-targeted strategies improve outcomes.
Study Design
Type
Cohort (n=96)
Structured PICO
Do increased plasma viscosity and erythrocyte aggregation predict myocardial infarction in patients with unstable angina?
P
Population
96 consecutive patients with unstable angina followed for six months or until angioplasty or bypass surgery.
E
Exposure
Plasma viscosity ≥ 1.38 mPa s and/or rate constant of erythrocyte aggregate formation ≥ 0.5 mPa
C
Comparator
Plasma viscosity < 1.38 mPa s and/or erythrocyte aggregation < 0.5 mPa
O
Outcome
Frequency of myocardial infarctionhard clinical
Main Result
Odds Ratio: 6.1 (95% CI 1.3–31)
Absolute Event Rate: 26.9% vs 5.7%
p-value: p=0.008
Increased plasma viscosity and erythrocyte aggregation are strong predictors of myocardial infarction in patients with unstable angina.
Cite This Study
Neumann et al. (1991) conducted a cohort in Unstable angina pectoris (n=96). Increased plasma viscosity (≥1.38 mPa s) vs. Plasma viscosity <1.38 mPa s was evaluated on Frequency of myocardial infarction (OR 6.1, 95% CI 1.3 to 31, p=0.008). Increased plasma viscosity (≥1.38 mPa s) was associated with a higher frequency of myocardial infarction in patients with unstable angina (OR 6.1; 95% CI 1.3-31; p=0.008).