Key result
Ultra-sensitive biological assay detects serum RNase and reveals ~20-fold higher levels in guinea pigs.
Population
Infectious RNA isolated from foot-and-mouth disease virus, calf-kidney cultures, and sera from man and…
Design
Preclinical
Authors
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Enables precise serum RNase quantification in research; leaves open human cardiovascular biomarker validation.
An ultra-sensitive biological assay using infectious RNA can detect ribonuclease concentrations as low as 0.1 mμg/ml.
Polatnick et al. (1960) studied this question. Biological assay for ribonuclease using infectious RNA was evaluated on Ribonuclease (RNase) detection sensitivity and serum levels. An ultra-sensitive biological assay detected ribonuclease concentrations as low as 0.1 mμg/ml, revealing levels of 0.02 to 0.1 μg/ml in most sera and 20- to 30-fold higher in guinea pigs.
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